@article {Salter:2016:0885-9701:E21,
author = "Salter, Katherine L. and McClure, J. Andrew and Foley, Norine C. and Sequeira, Keith and Teasell, Robert W.",
title = "Pharmacotherapy for Depression Posttraumatic Brain Injury: A Meta-analysis",
journal = "Journal of Head Trauma Rehabilitation",
volume = "31",
number = "4",
year = "2016",
publication date ="2016-07-01T00:00:00",
abstract = "
Objective:
To examine the effectiveness of pharmacotherapy for the treatment of depression following traumatic brain injury (TBI). 
Design:
Systematic review and meta-analysis. Multiple electronic databases were searched to identify relevant studies examining
effectiveness of pharmacotherapy for depression post-TBI. Clinical trials evaluating the use of pharmacotherapy in individuals with depression at baseline and using standardized assessments of depression were included. Data abstracted included sample size, antidepressant used, treatment timing/duration,
method of assessment, and results pertaining to impact of treatment. Study quality was assessed using a modified Jadad scale. 
Results:
Nine studies met criteria for inclusion. Pooled analyses based on reported means (standard deviations) from repeated assessments of depression
showed that, over time, antidepressant treatment was associated with a significant effect in favor of treatment (Hedges g = 1.169; 95% confidence interval, 0.849-1.489; P < .001). Similarly, when limited to placebo-controlled trials, treatment was associated with a significant
reduction in symptoms (standardized mean difference = 0.84; 95% confidence interval, 0.314-1.366; P = .002). 
Conclusion:
Pharmacotherapy after TBI may be associated with a reduction in depressive symptomatology. Given limitations within the available literature,
further well-powered, placebo-controlled trials should be conducted to confirm the effectiveness of antidepressant therapy in this population.",
pages = "E21-E32",
itemtype = "ARTICLE",
parent_itemid = "infobike://wk/htr",
issn = "0885-9701",
eissn = "1550-509X",
publishercode ="wk",
url = "http://www.ingentaconnect.com/content/wk/htr/2016/00000031/00000004/art00003",
doi = "doi:10.1097/HTR.0000000000000193",
keyword = "traumatic brain injury, meta-analysis, depression, pharmacotherapy"
}