@article {Zhang:January 2008:0920-5063:99,
	author = "Zhang, Haiyue",
	author = "Chang, Li",
	author = "Zhang, Bin",
	author = "Li, Peng",
	author = "Wang, Min",
	author = "Yao, Kang De",
	author = "Yang, Jun",
	author = "Yao, Fanglian",
	title = "Synthesis and characterization of microparticles made of carboxymethyloxysuccinic-acid-modified PLA-PEG co-polymer",
	journal = "Journal of Biomaterials Science, Polymer Edition",
	volume = "19",
	year = "January 2008",
	abstract = "A novel tri-block co-polymer, HO<SUB>2</SUB>C-PLA-PEG-PLA-CO<SUB>2</SUB>H (co-polymer II), with polybasic carboxylic acids as the end-groups was synthesized and characterized by IR and <SUP>1</SUP>H-NMR. Based on the successful synthesis of co-polymer II, water-soluble sodium salicylate and oil-soluble tetrandrine, used as model drugs, were loaded in the co-polymer microparticles prepared through a modified multiple emulsion method. The encapsulation efficiency and drug-releasing behaviour were also investigated. It is found that the microparticles of about 10 &#956;m in size are porous and can be produced from co-polymer II in better encapsulation efficiency (up to 86.65% and 55.94%) compared to those made from PLA/PEG/PLA (co-polymer I) (77.50% and 44.01%). The drug-release behaviour of co-polymer II exhibits an extended continuous release behaviour and the initial burst was reduced obviously. The results show that such functionalised PLA/PEG/PLA carrier provides higher drug encapsulation efficiency and better profiles.",
	pages = "99-111(13)",
	url = "http://www.ingentaconnect.com/content/vsp/bsp/2008/00000019/00000001/art00008"
	doi = "doi:10.1163/156856208783227677"
}