@article {Rong:September 2001:0171-9335:580, author = "Rong H.", author = "Boterberg T.", author = "Maubach J.", author = "Stove C.", author = "Depypere H.", author = "Van Slambrouck S.", author = "Serreyn R.", author = "De Keukeleire D.", author = "Mareel M.", author = "Bracke M.", title = "8-Prenylnaringenin, the phytoestrogen in hops and beer, upregulates the function of the E-cadherin/catenin complex in human mammary carcinoma cells", journal = "European Journal of Cell Biology", volume = "80", year = "September 2001", abstract = "

The E-cadherin/catenin complex is a powerful invasion suppressor in epithelial cells. It is expressed in the human MCF-7 breast cancer cell line family, but functionally defective in the invasive MCF-7/6 variant. Previous experiments have shown that IGF-I, tamoxifen, retinoic acid and tangeretin are able to upregulate the function of this complex in MCF-7/6 cells. We investigated the effect of 8-prenylnaringenin (8-PN), the phytoestrogen present in hops and beer, on aggregation, growth and invasion in MCF-7/6 cells. 8-PN was found to stimulate E-cadherin-dependent aggregation and growth of MCF-7/6 cells in suspension. These effects could be inhibited by the pure anti-estrogen ICI 182,780. 8-PN did not affect invasion of MCF-7/6 cells in the chick heart assay in vitro. In all these aspects 8-PN mimics the effects of 17beta-estradiol on MCF-7/6 cells.

", pages = "580-585(6)", url = "http://www.ingentaconnect.com/content/urban/251/2001/00000080/00000009/art00190" doi = "doi:10.1078/0171-9335-00190" }