@article {Lee:1 August 2000:0022-3573:1037,
	author = "Lee K.H.",
	author = "Hong H.S.",
	author = "Lee C.H.",
	author = "Kim C.H.",
	title = "Induction of Apoptosis in Human Leukaemic Cell Lines K562, HL60 and U937 by Diethylhexylphthalate Isolated from Aloe vera Linne",
	journal = "Journal of Pharmacy and Pharmacology",
	volume = "52",
	year = "1 August 2000",
	abstract = "We investigated the effect of diethylhexylphthalate (DEHP) from <I>Aloe vera</I> Linne on the apoptosis of human leukaemic cell lines K562, HL60 and U937 to examine its pharmacological activity.<P></P>At a level of 10&#160;<IMG SRC="/iso-ents/isogrk32/mu-s.gif" ALT="mu">g&#160;mL<SUP>-1</SUP> DEHP a significant anti-leukaemic effect was observed for all three cell lines, as measured by clonogenic assay. After treatment with 10&#160;<IMG SRC="/iso-ents/isogrk32/mu-s.gif" ALT="mu">g&#160;mL<SUP>-1</SUP> DEHP for 4&#160;h, agarose gel electrophoresis and flow cytometric analysis confirmed the occurrence of apoptosis.<P></P>These results indicate that DEHP isolated from <I>Aloe vera</I> Linne has a potent anti-leukaemic effect, and thus represents a new type of pharmacological activity with respect to human leukaemic cells.",
	pages = "1037-1041(5)",
	url = "http://www.ingentaconnect.com/content/rpsgb/jpp/2000/00000052/00000008/art00018"
	doi = "doi:10.1211/0022357001774778"
}