@article {Modell:1 July 2000:0092-623X:231,
	author = "Modell, Jack G.",
	author = "May, Roberta S.",
	author = "Katholi, Charles R.",
	title = "Effect of Bupropion-SR on Orgasmic Dysfunction in Nondepressed Subjects: A Pilot Study",
	journal = "Journal of Sex and Marital Therapy",
	volume = "26",
	year = "1 July 2000",
	abstract = "The objective of this study was to determine whether the aminoketone antidepressant bupropion has beneficial effects in orgasmic dysfunction. <B>Design:</B> Single-blind, sequential treatment order of three weeks each: placebo, bupropion-SR 150 mg/day, bupropion-SR 300 mg/ day <B>Subjects:</B> Nondepressed women (<I>n</I> = 20) and men (<I>n</I> = 10) having nonphysiologic orgasmic delay or inhibition <B>Main Outcome Measures:</B> Reported difficulty or delay in achieving orgasm, satisfaction with orgasm and erectile function, and subjective impressions of drug effect <B>Results:</B> In the women, there were significant improvements relative to baseline (<I>p</I> &#60; .01) on both doses of bupropion-SR in all measured aspects of sexual function, and significant improvements relative to placebo (<I>p</I> &#60; .05) in overall sexual satisfaction on both doses and satisfaction with intensity of orgasm on 150 mg/day (300 mg/day, <I>p</I> = .10). In the men, significant improvements over baseline (<I>p</I> &#60; .01) were observed with both doses in overall sexual satisfaction, ability to achieve an erection, and delay in reaching orgasm/ejaculation; significant improvements relative to placebo (<I>p</I> &#60; .05) were observed in overall sexual satisfaction on both doses, ability to achieve erection on 150 mg/ day, and delay in orgasm/ejaculation on 150 mg/day. Seventy percent of subjects reported improvement in libido, arousal, or orgasmic function during bupropion administration. relative to placebo (<I>p</I> &#60; .05) were observed in overall sexual satisfaction on both doses, ability to achieve erection on 150 mg/ day, and delay in orgasm/ejaculation on 150 mg/day. Seventy percent of subjects reported improvement in libido, arousal, or orgasmic function during bupropion administration. <B>Conclusions:</B> Bupropion-SR may be a useful agent for treating orgasmic delay and inhibition, and possibly disorders of sexual arousal. The results argue against bupropion&#8217;s apparent prosexual effect in depressed patients being simply a result of its antidepressant activity.",
	pages = "231-240(10)",
	url = "http://www.ingentaconnect.com/content/routledg/usmt/2000/00000026/00000003/art00002"
	doi = "doi:10.1080/00926230050084623"
}