@article {Korner:September 2008:1360-7863:625, author = "Korner, Alex", author = "Lopez, Ana", author = "Lauritzen, Lise", author = "Andersen, Per", author = "Kessing, Lars", title = "Delusional disorder in old age and the risk of developing dementia-a nationwide register-based study", journal = "Aging and Mental Health", volume = "12", year = "September 2008", abstract = "Objective: To examine whether very late first-contact delusional disorder carries a risk for later development of dementia. Methods: By linkage of the psychiatric and the somatic nationwide registers of all out- and in-patients with hospital contact in Denmark, we included all 60+ patients with first ever from 1 January 1994 to 31 December 2001 with the index main diagnosis: delusional disorder. First contact osteoarthritis patients as well as the general population were used as controls. A total of 1437 patients with persistent delusional disorder and 7302 patients with osteoarthritis were included. Median follow-up time until first diagnosis of dementia at discharge was 1.87 and 4.40 years, respectively. The probability of getting a dementia diagnosis was estimated using Poisson regression models with dementia as the outcome of interest. Results: Patients with very late first-contact delusional disorder had an 8.14 (95% CI, 6.51; 10.19) times increased rate of subsequently developing dementia compared with very late first contact osteoarthritis patients. Compared with the general population the rate ratio was 5.49 (95% CI, 4.81; 6.26). Conclusion: Very late first-contact delusional disorder increases the risk of subsequently getting a diagnosis of dementia 5-8 times compared with osteoarthritis patients and the general population.", pages = "625-629(5)", url = "http://www.ingentaconnect.com/content/routledg/camh/2008/00000012/00000005/art00012" doi = "doi:10.1080/13607860802343118" }