Torsion/Detorsion of the Testis Does Not Modify Responses to Nitric Oxide in Rat Isolated Penile Bulb

Authors: Ozkan, Melike H.1; Vural, İ. Mert2; Moralioglu, Serdar3; Uma, Serdar1; Sarioglu, Yusuf2

Source: Basic & Clinical Pharmacology & Toxicology, Volume 101, Number 2, August 2007 , pp. 117-120(4)

Publisher: Blackwell Publishing

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Abstract:

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Ischaemia-reperfusion damage induced by torsion/detorsion of the testicles may be a causative factor leading to erectile dysfunction through oxidative stress-dependent changes in the responses of the penile bulb, an erectile tissue of the penis. We aimed at investigating the effects of unilateral testicular torsion/detorsion (2 or 24 hr) treatment on relaxations induced by electrical field stimulation and sodium nitroprusside in rat isolated penile bulb. Male Sprague-Dawley rats used in the study were divided into two groups. The treatment group was subjected to unilateral torsion followed by detorsion for 2 or 24 hr, while the control group underwent only sham operation. For in vitro organ bath experiments, penile bulbs were isolated and responses to relaxant agents and electrical field stimulation (70 V, 1 msec., 0.5-8 Hz, 5 sec.) were recorded on a computer-based data acquisition system via a force displacement transducer. In tissues precontracted with phenylephrine (3 × 10−6 M), relaxations induced by electrical field stimulation were not significantly different before and after 2 or 24 hr of detorsion. Similarly sodium nitroprusside- (10−8-3 × 10−6 M) and papaverine-induced (10−7-10−4 M) relaxations were also found unchanged in the detorsion group compared to control. In conclusion, spermatic cord torsion did not lead to impairment in nitric oxide-mediated relaxant responses of the rat isolated penile bulb.

Document Type: Research article

DOI: 10.1111/j.1742-7843.2007.00087.x

Affiliations: 1: Department of Pharmacology, Faculty of Pharmacy, Hacettepe University, Ankara, 2: Department of Pharmacology, Faculty of Medicine, Gazi University, Ankara and 3: Department of Pediatric Surgery, Faculty of Medicine, Gazi University, Ankara, Turkey

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