IngentaConnect Association of Angiotensin-Converting Enzyme Gene Insertion/Delet...

Authors: Nacak, Muradiye¹; Erbagci, Zulal²; Buyukafsar, Kansu¹; Yurtsever, Ahmet Sencer¹; Tiftik, Rukiye Nalan¹

Source: Basic & Clinical Pharmacology & Toxicology, Volume 101, Number 2, August 2007 , pp. 101-103(3)

Abstract:

Angiotensin-converting enzyme (ACE) plays an important role in the physiological control of blood pressure and inflammation. Insertion/deletion (I/D) polymorphism of the gene for ACE was investigated in relation to cardiovascular, cerebrovascular, neurodegenerative and inflammatory diseases. The purpose of the present study was to investigate the possible association between allergic contact dermatitis and insertion/deletion polymorphism of the ACE gene. A total of 90 patients with allergic contact dermatitis and 160 control persons were enrolled in the present study. ACE I/D genotypes were determined by the polymerase chain reaction. Allelic frequencies and genotype distribution of the ACE I/D polymorphism in the patient group were significantly different from control group (ACE II genotype 30.0% versus 17.5%, P = 0.022; ACE I allele 51.7% versus 39.4%, P = 0.008). Our data suggest that the ACE polymorphism could be a risk factor for patients with allergic contact dermatitis.

Document Type: Research article

DOI: 10.1111/j.1742-7843.2007.00077.x

Affiliations: 1: Department of Pharmacology, Faculty of Medicine, Mersin University, Mersin, Turkey, and 2: Department of Dermatology, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.16 plus tax Refund Policy

Association of Angiotensin-Converting Enzyme Gene Insertion/Deletion Polymorphism with Allergic Contact Dermatitis