N-Benzoyl-D-phenylalanine Attenuates Brain Acetylcholinesterase in Neonatal Streptozotocin-Diabetic Rats
Authors: Ashokkumar, Natarajan1; Pari, Leelavinothan; Ramkumar, Kunga Mohan2
Source: Basic & Clinical Pharmacology & Toxicology, Volume 99, Number 3, September 2006 , pp. 246-250(5)
Publisher: Blackwell Publishing
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Abstract:
: The effect of hyperglycaemia due to experimental diabetes in male Wistar rats causes a decrease in the level of acetylcholinesterase (AChE) with significant increase in lipid peroxidative markers: thiobarbituric acid-reactive substances (TBARS) and hydroperoxides in brains of experimental animals. The decreased activity of both salt soluble and detergent soluble acetylcholinesterase observed in diabetes may be attributed to lack of insulin which causes specific alterations in the level of neurotransmitter, thus causing brain dysfunction. Administration of non-sulfonylurea drug N-benzoyl-D-phenylalanine (NBDP) could protect against direct action of lipid peroxidation on brain AChE and in this way it might be useful in the prevention of cholinergic neural dysfunction, which is one of the major complications in diabetes.Document Type: Research article
DOI: 10.1111/j.1742-7843.2006.pto_487.x
Affiliations: 1: Department of Biochemistry, Faculty of Science, Annamalai University, Annamalainagar-608 002, Tamil Nadu, and 2: Department of Biotechnology, School of Engineering and Technology, Bharathidasan University, Tiruchirappalli - 620 024, Tamil Nadu, India
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