IngentaConnect Spinal epidural lipomatosis following haploidentical allogeneic b...

Authors: Resnick, Igor B¹; Gomori, John M²; Kiselgoff, David²; Lossos, Alex³; Zilberman, Irina¹; Miron, Svetlana¹; Bitan, Menachem¹; Or, Reuven¹; Slavin, Shimon¹; Shapira, Michael Y¹

Source: Clinical Transplantation, Volume 18, Number 6, December 2004 , pp. 762-765(4)

Publisher: Blackwell Publishing

Abstract:

Resnick IB, Gomori JM, Kiselgoff D, Lossos A, Zilberman I, Miron S, Bitan M, Or R, Slavin S, Shapira MY.

Spinal epidural lipomatosis following haploidentical allogeneic bone marrow transplantation for non-Hodgkin lymphoma.

Clin Transplant 2004 DOI: 10.1111/j.1399-0012.2004.00290.x

Spinal epidural lipomatosis, is a very rare condition, usually seen as an uncommon complication of Cushing's syndrome secondary to chronic steroid therapy leading to increased fat deposits in the epidural space. Case report:

We report the first documented case of acute symptomatic spinal epidural lipomatosis in a patient with relapsed non-Hodgkin lymphoma. The patient underwent an allogeneic bone marrow transplantation (BMT) and a month of steroid treatment for acute graft vs. host disease (GvHD). He presented with a mild to moderate Cushing's syndrome and minimal obesity. He progressed rapidly to paraparesis, sensory deficit, urinary incontinence and finally respiratory arrest complicated with staphylococcal sepsis. Conclusion:

Epidural lipomatosis, with subacute thecal sac compression, is a possible life-threatening complication of relatively short-term systemic glucocorticoid therapy for GvHD in BMT setting.

Keywords: bone marrow transplantation; epidural lipomatosis; spinal epidural lipomatosis

Document Type: Research article

DOI: 10.1111/j.1399-0012.2004.00290.x

Affiliations: 1: Bone Marrow Transplantation and Cancer Immunotherapy 2: Radiology 3: Neurology, Hadassah University Hospital, Jerusalem, Israel

We were unable to expand this article. Please try again later. If the problem continues, please contact help@ingentaconnect.com.

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.16 plus tax Refund Policy