Accelerated rejection following offspring-to-mother and husband-to-wife transplants

Authors: Rosenberg, Jerry C.¹; Jones, Bruce²; Oh, Henry²

Source: Clinical Transplantation, Volume 18, Number 6, December 2004 , pp. 729-733(5)

Publisher: Blackwell Publishing

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Abstract:

Rosenberg JC, Jones B, Oh H. Accelerated rejection reactions following offspring-to-mother and husband-to-wife renal transplants.

Clin Transplant 2004 DOI: 10.1111/j.1399-0012.2004.00250.x

It has been demonstrated that graft survival rates of offspring-to-mother and husband-to-wife renal transplants are equivalent to those of other living donors. Although the vast majority of these transplants proceed without incident, we have encountered several instances of delayed accelerated rejections that are not predicted by a positive cross-match. The accelerated rejection can result from an anamnestic reaction subsequent to the in utero exposure of the mother to human leukocyte antigen (HLA) antigens of the fetus with sensitization developing during the pregnancy.

Keywords: accelerated rejection; anamnestic reaction; offspring-to-mother transplant; husband-to-wife transplant; immunologic mechanisms of rejection

Document Type: Research article

DOI: 10.1111/j.1399-0012.2004.00250.x

Affiliations: 1: Transplantation Society of Michigan, Ann Arbor, MI 2: St John Hospital Transplant Center, Detroit, MI, USA

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