IngentaConnect Intratubular calcification in a post-renal transplanted patient w...

Authors: Iguchi, Seitaro¹; Nishi, Shinnichi¹; Shinbo, Junnichi¹; Iino, Noriaki¹; Kazama, J Junichiro¹; Shimada, Hisaki¹; Ueno, Mitsuhiro¹; Saitou, Kazuhide²; Tanigawa, Toshiki²; Takahashi, Kouta²; Gejyo, Fumitake¹

Source: Clinical Transplantation, Volume 15, Supplement 5, November 2001 , pp. 51-54(4)

Publisher: Blackwell Publishing

Abstract:

Iguchi S, Nishi S, Shinbo J, Iino N, Kazama JJ, Shimada H, Ueno M, Saitou K, Tanigawa T, Takahashi K, Gejyo F. Intra-tubular calcification in a post-renal transplanted patient with secondary hyperparathyroidism. Clin Transplantation 2001: 15 (Supplement 5): 51-54. ©Munksgaard, 2001

In this article, we present a case in which marked intratubular calcification occurred in the transplanted kidney. The patient received living renal transplantation without control of severe secondary hyperparathyroidism, and the tacrolimus hydrate was used as an immunosuppressive agent, the adverse effects of which can induce intratubular calcification. Biopsy of the renal allograft revealed many intratubular calcifications in the cortex region of the specimen, although the histological grade was borderline for the Banff classification. The pathogenic causes of intratubular calcification were difficult to distinguish from the adverse effects of tacrolimus and the uncontrolled hyperparathyroidism.

Keywords: intratubular calcification; nephrocalcinosis; renal transplantation; secondary hyperparathyroidism

Document Type: Research article

DOI: 10.1034/j.1399-0012.2001.0150s5051.x

Affiliations: 1: Internal Medicine II, Niigata University School of Medicine, Niigata-city, Japan, 2: Urology, Niigata University School of Medicine, Niigata-city, Japan

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Intratubular calcification in a post-renal transplanted patient with secondary hyperparathyroidism