@article {Walker:November 2005:0303-6979:1163,
author = "Walker, Clay",
author = "Preshaw, Philip M.",
author = "Novak, John",
author = "Hefti, Arthur F.",
author = "Bradshaw, Mark",
author = "Powala, Christopher",
title = "Long-term treatment with sub-antimicrobial dose doxycycline has no antibacterial effect on intestinal flora",
journal = "Journal of Clinical Periodontology",
volume = "32",
year = "November 2005",
abstract = "Walker C, Preshaw PM, Novak J, Hefti AF, Bradshaw M, Powala C. Long-term treatment with sub-antimicrobial dose doxycycline has no antibacterial effect on intestinal flora. J Clin Periodontol 2005; 32: 1163-1169. doi: 10.1111/j.1600-051X.2005.00840.x. © Blackwell Munksgaard 2005. Abstract Aim: The purpose of this study was to determine if a 9-month regimen of sub-antimicrobial doxycycline (20 mg, bid) had an effect on either the intestinal or the vaginal microflora. Material and Methods: A total of 69 periodontally diseased subjects were randomized to receive drug or placebo control for a 9-month period. Stool specimens and vaginal swabs were collected at baseline and after 3 and 9 months of therapy. Samples were examined for total anaerobic counts, opportunistic pathogens, and doxycycline-resistant (⩾4 μg/ml) bacteria. All isolates that survived sub-culture were identified and their susceptibilities determined to six antibiotics. Analyses were performed to determine if treatment differences were present. Results: The only statistically significant differences (p<0.05) between the two treatment groups occurred in the doxycycline-resistant counts at the baseline sample period for the faecal samples. This imbalance was before treatment initiation and the administration of the study drug. No between-treatment differences were detected at either the 3- or 9-month sample period either in the predominant bacterial taxa present or in their antibiotic susceptibilities. Conclusions: There was no evidence that sub-antimicrobial doxycycline treatment exerted an effect on the composition or doxycycline resistance level of either the faecal or the vaginal microflora.",
pages = "1163-1169(7)",
url = "http://www.ingentaconnect.com/content/mksg/cpe/2005/00000032/00000011/art00008"
doi = "doi:10.1111/j.1600-051X.2005.00840.x"
}