Photopatch tests: an Italian multicentre study from 2004 to 2006

Authors: Pigatto, PaoloDaniele; Guzzi, Gianpaolo¹; Schena, Donatella²; Guarrera, Marcella³; Foti, Caterina⁴; Francalanci, Stefano⁵; Cristaudo, Antonio⁶; Ayala, Fabio⁷; Vincenzi, Colombina⁸

Source: Contact Dermatitis, Volume 59, Number 2, August 2008 , pp. 103-108(6)

Publisher: Blackwell Publishing

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Abstract:

Background:

Evaluation of possible photoallergic contact dermatitis in at-risk populations is often not undertaken, and an agreed methodology for investigation is uncommonly used. Objectives:

We conducted a retrospective multicentre study to determine the prevalence of photoallergic contact dermatitis in Italy. Methods:

A total of 1082 patients with histories and clinical features suggestive of photoallergic contact dermatitis were evaluated. All the patients had undergone photopatch testing with allergens proposed for Italy as well as other substances suggested by each patient's personal history. Results:

234 patients (21.6%) were positive to at least one test substance of the standard photopatch testing series or to added substances. 234 patients (21.6%) were positive to at least one substance with a total of 290 reactions. 204 of the reactions were typically photoallergic; 68 reactions were allergic and within this group 10 were photoaugmented reactions; 18 reactions were considered to be phototoxic. Conclusion:

The predominant group of photoallergens was drugs, followed by organic UV filters and antimicrobial agents.

Keywords: photoallergic contact dermatitis; photopatch tests; topical arylpropionic derivatives; topical non-steroidal anti-inflammatory drugs; ultraviolet filters

Document Type: Research article

DOI: 10.1111/j.1600-0536.2008.01374.x

Affiliations: 1: Italian Association for Metals and Biocompatibility Research, 20122 Milan, Italy 2: Department of Biomedical and Surgical Science, Dermatology Section, University of Verona, 37100 Verona , Italy 3: Section of Dermatology, DISEM, University School of Medicine, 16132 Genova, Italy 4: Department of Internal Medicine, Immunology and Infectious Diseases, Unit of Dermatology, University of Bari, 70124 Bari, Italy 5: Department of Dermatological Sciences, University of Florence, 50121 Florence, Italy 6: San Gallicano Dermatological Institute, IRCCS, 00144 Rome, Italy 7: Department of Dermatology, University of Naples Federico II, 80131 Napoli, Italy 8: Department of Dermatology, University of Bologna, 40126 Bologna, Italy

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