IngentaConnect Are concomitant patch test reactions to epoxy resin and BIS-GMA i...

Authors: Geier, Johannes; Lessmann, Holger¹; Uter, Wolfgang²; Schnuch, Axel¹

Source: Contact Dermatitis, Volume 57, Number 6, December 2007 , pp. 376-380(5)

Abstract:

Background:

Despite rare simultaneous exposure, concomitant sensitisation to bisphenol A diglycidyl methacrylate (BIS-GMA) and epoxy resin frequently occurs. Immunological cross-reactivity has not been proven by animal experiments so far. Objective:

Our objective was to examine cross-reactivity epidemiologically by analysing data of the Information Network of Departments of Dermatology (IVDK). Patients/methods:

From 2001 to 2005, 3,777 patients were patch tested with epoxy resin and BIS-GMA in the IVDK. We retrospectively analysed concomitant reactions to these allergens and to BIS-GMA and selected methacrylates. Additionally, we compared clinical characteristics of patients reacting to both, epoxy resin and BIS-GMA, with those of patients reacting to epoxy resin or BIS-GMA only. Results:

185 patients reacted to epoxy resin, and 40 to BIS-GMA. Of the latter, 34 reacted to epoxy resin. There was no difference concerning exposure between the above-mentioned groups of patients. Concomitant reactions to BIS-GMA and methacrylates hardly ever occurred. Conclusions:

Considering the fact that very few patients had been potentially exposed to BIS-GMA and that 85% of those reacting to BIS-GMA also reacted to epoxy resin, we conclude that our data are presumably indicative of immunological cross-reactivity. A verification of this hypothesis by animal experiments would be promising.

Keywords: BIS-GMA; bisphenol A diglycidyl methacrylate; CAS 1565-94-2; cross-reaction; diglycidyl ether of bisphenol A; epoxy resin; methacrylates

Document Type: Research article

DOI: 10.1111/j.1600-0536.2007.01249.x

Affiliations: 1: Information Network of Departments of Dermatology, University of Göttingen 2: Department of Medical Informatics, Biometry and Epidemiology, University of Erlangen/Nürnberg, Germany

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Are concomitant patch test reactions to epoxy resin and BIS-GMA indicative of cross-reactivity?