IngentaConnect 1,2-Benzisothiazolin-3-one in disposable polyvinyl chloride glove...

Authors: Aalto-Korte, Kristiina; Ackermann, Leena¹; Henriks-Eckerman, Maj-Len²; Välimaa, Jarmo²; Reinikka-Railo, Hely³; Leppänen, Esa³; Jolanki, Riitta⁴

Source: Contact Dermatitis, Volume 57, Number 6, December 2007 , pp. 365-370(6)

Publisher: Blackwell Publishing

Abstract:

Background:

Benzisothiazolinone is used as a slimicide in the manufacture of disposable powder-free polyvinyl chloride (PVC) gloves. We recently reported 6 patients from dentistry and health care probably sensitized to benzisothiazolinone in PVC gloves. Objective:

The study aimed to investigate how widely disposable PVC gloves for medical use on the Finnish market in 2006 contain benzisothiazolinone and to report new cases from 2 clinics in Helsinki. Methods:

31 brands of disposable PVC gloves were analysed for their benzisothiazolinone content. We looked through the patient material of Helsinki University Central Hospital to find benzisothiazolinone allergic patients. We also described 3 previously unpublished benzisothiazolinone allergic patients from Finnish Institute of Occupational Health. Results:

9 (30%) of the 31 glove brands contained 3-26 p.p.m. benzisothiazolinone. From the 2 clinics, we found 5 new benzisothiazolinone allergic patients who had used PVC gloves containing benzisothiazolinone. In addition, 3 patients had used disposable PVC gloves whose benzisothiazolinone content remained unknown. Conclusions:

In Finland, benzisothiazolinone in powder-free PVC gloves has caused a small epidemic of allergic contact dermatitis in dental personnel and other health care workers. 1/3 of the disposable PVC gloves contained some benzisothiazolinone. A concentration of 20 p.p.m. benzisothiazolinone in a glove seems to be enough for sensitization.

Keywords: biocide; CAS 2634-33-5; contact allergy; dental nurses; dentists; health care; occupational

Document Type: Research article

DOI: 10.1111/j.1600-0536.2007.01278.x

Affiliations: 1: Skin and Allergy Hospital, University Central Hospital, FI-00029 HUS 2: Finnish Institute of Occupational Health, Chemical Agents, Turku, FI 20500 3: National Agency for Medicines, PO Box 55, FI-00301 Helsinki, Finland 4: Finnish Institute of Occupational Health (FIOH), Control of Hypersensitivity Diseases, Topeliuksenkatu 41 a A, FI-00250 Helsinki

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1,2-Benzisothiazolin-3-one in disposable polyvinyl chloride gloves for medical use