IngentaConnect Citral a fragrance allergen and irritant

Authors: Heydorn S.¹; Menné T.¹; Andersen K.E.²; Bruze M.³; Svedman C.³; White I.R.⁴; Basketter D.A.⁵

Source: Contact Dermatitis, Volume 49, Number 1, July 2003 , pp. 32-36(5)

Abstract:

Citral is a well known contact allergen and a contact irritant. Routine patch testing in the past may have been restricted because of possible irritant (IR) patch test responses. 586 consecutive patients, with hand eczema, were patch tested with a selection of fragrances including citral 2% petrolatum and the European standard series. 28 of the patients showed a positive patch test reaction (+ to +++) to citral and 82 at least 1 IR patch test reaction and no positive patch test reaction to citral. A statistically significant association between a positive patch test reaction to citral and positive patch test reactions to other fragrances compared with IR reactions (n = 82) was established. The difference regarding fragrance history found between those with IR and positive reactions to citral was not significant. Citral could be an allergen and/or irritant, worthy of further more extensive studies.

Keywords: citral; contact allergen; contact irritant; fragrance; patch testing

Document Type: Research article

DOI: 10.1111/j.0105-1873.2003.00144.x

Affiliations: 1: Department of Dermatology, Gentofte Hospital, University of Copenhagen, 2: Department of Dermatology, Odense University Hospital, University of Southern Denmark, Denmark, 3: Department of Occupational and Environmental Dermatology, Malmö University Hospital, Lunds University, Malmö, Sweden, 4: St John's Institute of Dermatology, St Thomas' Hospital, London, and 5: SEAC Toxicology, Unilever Research, Sharnbrook, UK

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