Lipoprotein(a) as a risk factor for maternal cardiovascular disease mortality in kindreds with familial combined hyperlipidemia or familial hypertriglyceridemia

Authors: Kim, H¹; Marcovina, SM²; Edwards, KL¹; McKnight, B³; Bradley, CM¹; McNeely, MJ⁴; Psaty, BM⁵; Motulsky, AG⁶; Austin, MA¹

Source: Clinical Genetics, Volume 60, Number 3, September 2001 , pp. 188-197(10)

Publisher: Blackwell Publishing

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Abstract:

Most but not all epidemiologic studies have shown that lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease (CVD). Lp(a) levels are also strongly genetically influenced. The purpose of this study was to evaluate the association between Lp(a) levels in adult offspring and parental CVD mortality in 61 kindreds with familial forms of hyperlipidemia. The study sample consisted of offspring-parent pairs in which offspring had fasting Lp(a) measurements and parents had 20-year vital status data and standardized cause-of-death classification if deceased. Linear regression analyses, using a robust variance estimator, were performed separately for 241 offspring with known maternal history (114 mothers) and 194 offspring with known paternal history (93 fathers). Maternal history of CVD mortality was significantly (p=0.004) associated with 2.4-fold higher median Lp(a) levels in offspring compared with those with no maternal history, independent of diabetes, lipid-lowering medications and hormone use. No association was observed between paternal CVD mortality and offspring Lp(a) levels (p=0.505). Adjusting for apolipoprotein(a) kringle 4 number did not alter these parent-specific associations. In conclusion, Lp(a) levels in offspring may be associated with maternal but not paternal history of CVD mortality. This parent-specific finding needs to be confirmed in other samples of high-risk families.

Keywords: cardiovascular disease; hyperlipidemic families; lipoprotein(a); parental history

Document Type: Research article

DOI: 10.1034/j.1399-0004.2001.600304.x

Affiliations: 1: Department of Epidemiology, School of Public Health and Community Medicine, 2: Division of Metabolism, Endocrinology, and Nutrition, Department of Medicine, 3: Department of Biostatistics, School of Public Health and Community Medicine, 4: Division of General Internal Medicine, Department of Medicine, School of Medicine, 5: Departments of Medicine, Epidemiology, and Health Services, Cardiovascular Health Research Unit, Schools of Medicine and Public Health and Community Medicine, 6: Division of Medical Genetics, Departments of Medicine and Genetics,

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