IngentaConnect Physical activity modulates the effect of a lipoprotein lipase mu...

Authors: Boer, Jolanda MA¹; Kuivenhoven, Jan Albert²; Feskens, Edith JM¹; Schouten, Evert G³; Havekes, Louis M⁴; Seidell, Jacob C¹; Kastelein, John JP²; Kromhout, Daan⁵

Source: Clinical Genetics, Volume 56, Number 2, August 1999 , pp. 158-163(6)

Publisher: Blackwell Publishing

Abstract:

We investigated interactions between a mutation (D9N) in the lipoprotein lipase (LPL) gene and physical activity, as well as other lifestyle factors, on lipid traits in a population-based sample of Dutch men and women (n=379). We used questionnaire information to classify physical activity, alcohol consumption, and smoking habits, while overweight was defined as a body mass index (BMI)> 25 kg/m². Non-fasting blood samples were used for the determination of lipid traits and the D9N genotype. Fifteen subjects (4%) carried the mutation. They presented with higher levels of total cholesterol, apolipoprotein (apo) B and triglycerides compared to non-carriers. While no interactions with overweight, alcohol consumption, and smoking were found, a strong interaction between the D9N mutation and physical activity became apparent. Physically inactive D9N carriers (n=5) had considerably higher total cholesterol (+2 mmol/l, p≤0.0001) and apo B levels (+63 mg/dl, p≤0.0001) compared to non-carriers of this mutation, whereas their high-density lipoprotein (HDL)-cholesterol concentrations were lower (−0.22 mmol/l, p<0.05). This was not the case for physically active D9N carriers (n=10).

In conclusion, a common variant of the LPL gene (D9N) adversely affects plasma lipid and lipoprotein profiles. However, the unfavorable consequences may be counteracted by physical activity.

Keywords: D9N mutation; gene-environment interaction; lipid traits; lipoprotein lipase; physical activity

Document Type: Research article

DOI: 10.1034/j.1399-0004.1999.560212.x

Affiliations: 1: Department of Chronic Disease Epidemiology, 2: Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, 3: Division of Human Nutrition and Epidemiology, Wageningen Agricultural University, Wageningen, 4: TNO-Prevention and Health, Gaubius Laboratory Leiden and Departments of Cardiology and Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands 5: Division of Public Health Research, National Institute of Public Health and the Environment, Bilthoven,

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Physical activity modulates the effect of a lipoprotein lipase mutation (D9N) on plasma lipids and lipoproteins