Allele distribution at the FMR1 locus in the general Chinese population

Authors: Chiang, Shu-Chuan1; Lee, Yu-May2; Wang, Tso-Ren1; Hwu, Wuh-Liang1

Source: Clinical Genetics, Volume 55, Number 5, May 1999 , pp. 353-356(4)

Publisher: Blackwell Publishing

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content

Abstract:

Fragile X syndrome is an important disease of hereditary mental retardation. Its prevalence in the Chinese population is not clear. We amplified FMR1 CGG repeats from male newborns' blood spots. Approximately 45% of the males had 28 CGG repeats and another 19% had 29 repeats. Besides this major peak, there was a second peak at 34 and 35 repeats. From the 1000 males studied, 3 were found to have repeat numbers in the high borderline range (each with 50, 52 and 53 repeats). This result provides a low but significant risk of fragile X syndrome in the Chinese population.

Keywords: CGG repeat; Chinese; FMR1; fragile X syndrome

Document Type: Research article

DOI: 10.1034/j.1399-0004.1999.550509.x

Affiliations: 1: Department of Medical Genetics and Pediatrics, College of Medicine, National Taiwan University, 2: Institute of Biological Chemistry, Academia Sinica, Taiwan, Republic of China

The full text electronic article is available for purchase. You will be able to download the full text electronic article after payment.

$50.16 plus tax      Refund Policy

 

OR

Back to top

Key:
Free Content - Free Content
New Content - New Content
Subscribed Content - Subscribed Content
Free Trial Content - Free Trial Content
Share this item with others: These icons link to social bookmarking sites where readers can share and discover new web pages.
Page Help Click here for Page Help
Shopping cart
Tools
Sign in






Need to register?
Sign up here
Text size: A | A | A | A