Inhibition of T-cell responses by CD4 on an antigen-presenting cell

Author: HANSEN, TORBJØRN

Source: Apmis, Volume 114, Number 1, January 2006 , pp. 32-38(7)

Publisher: Blackwell Publishing

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Abstract:

Hansen T. Inhibition of T-cell responses by CD4 on an antigen-presenting cell. APMIS 2006;114:32–8.

In addition to T-helper cells, CD4 is expressed on monocytes, macrophages and dendritic cells. To see whether CD4 molecules on antigen-presenting cells affect T-cell responses, we expressed CD4 on Raji cells, and compared positive and negative cells as stimulator cells for peripheral blood mononuclear cells in mixed lymphocyte reactions. We found that expression of CD4 on Raji had an inhibitory effect on production of IFN-γ and other cytokines.

Keywords: CD4; T-cell activation; antigen-presenting cells

Document Type: Research article

DOI: 10.1111/j.1600-0463.2006.apm_339.x

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