IngentaConnect Uncoupling activation-induced modulation of CD16 and CD69 in CD56...

Authors: Barboza J.M.¹; Salmen S.¹; Cova J.A.¹; Albarrán B.¹; Goncalves L.¹; Borges L.¹; Hernández M.¹; Berrueta L.¹

Source: Apmis, Volume 110, Number 5, May 2002 , pp. 415-422(8)

Publisher: Blackwell Publishing

Abstract:

The immune system of HIV+ patients is chronically activated, which has been associated with a detrimental effect on both innate and acquired immunity during AIDS. We analyzed the expression and modulation of the triggering markers CD69 and CD16 in CD56⁺ cells from 18 asymptomatic HIV+ individuals and 8 AIDS patients, compared with 21 seronegative subjects. We observed a diminished PMA-induced CD16 downregulation in AIDS patients (p<0.01), associated with low numbers of CD4⁺ cells (p<0.02). Furthermore, an enhanced unstimulated expression of CD69 in asymptomatic HIV+ patients (p<0.05) was shown. AIDS patients could not efficiently upregulate PHA-dependent CD69 expression (p<0.05), which correlated with low CD4⁺ counts (p< 0.05). These abnormalities in CD16 and CD69 modulation were recorded in patients under highly active antiretroviral therapy (HAART). Our results demonstrate an altered modulation of two functionally relevant receptors in CD56⁺ cells from AIDS patients, contributing to our understanding of the immunopathogeny of NK cell dysfunction during disease progression.

Keywords: CD56+ cells; NK cells; HIV; CD69; CD16; modulation; PKC; activation

Document Type: Research article

DOI: 10.1034/j.1600-0463.2002.100508.x

Affiliations: 1: Instituto de Inmunología Clínica, Facultad de Medicina, Universidad de Los Andes, Mérida-Venezuela

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Uncoupling activation-induced modulation of CD16 and CD69 in CD56+ cells during AIDS