Synergistic effects of 1,25-Dihydroxyvitamin D3 and TGF-bgr1 on the production of insulin-like growth factor binding protein 3 in human bone marrow stromal cell cultures

Authors: Kveiborg M.; Flyvbjerg A.1; Kassem M.

Source: Apmis, Volume 110, Number 5, May 2002 , pp. 410-414(5)

Publisher: Blackwell Publishing

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Abstract:

1,25-Dihydroxyvitamin D3 (calcitriol), transforming growth factor-bgr (TGF-bgr), and insulin-like growth factors (IGFs) are all important bone regulatory factors known to affect proliferation and differentiation of human bone-forming cells (osteoblasts). We have previously shown that TGF-bgr1 increased IGF-I and IGF-binding protein (IGFBP)-3 production in human bone marrow stromal (hMS) osteoblast progenitors and calcitriol stimulated IGFBP-3 and IGFBP-4 production. As interaction between signaling pathways of these factors has been reported, the present study aimed at examining the concerted actions on components of the IGF-system. We report that co-treatment with TGF-bgr1 and calcitriol resulted in a synergistic increase in IGFBP-3 production, thereby suggesting that the effects of these factors on hMS osteoblast differentiation may involve the observed increase in IGFBP-3.

Keywords: 1,25-Dihydroxyvitamin D3; transforming growth factor-bgr; insulin-like growth factors; insulin-like growth factor binding proteins; osteoblasts

Document Type: Research article

DOI: 10.1034/j.1600-0463.2002.100507.x

Affiliations: 1: Medical Research Laboratories, Institute of Experimental Clinical Research, University of Aarhus and

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