IngentaConnect Reduced full-field electroretinogram (ERG) in a patient treated w...

Authors: Ponjavic, Vesna¹; Gränse, Lotta¹; Stigmar, Elisabeth Bengtsson¹; Andréasson, Sten¹

Source: Acta Ophthalmologica Scandinavica, Volume 82, Number 1, February 2004 , pp. 96-99(4)

Abstract:

. Purpose:

To examine retinal function in a patient with decreased vision possibly due to treatment with methotrexate. Methods:

Ophthalmological examination included testing of visual acuity (VA), fundus inspection, fundus photography and kinetic perimetry. Retinal function was tested objectively with three electrophysiological methods: full-field electroretinography (ERG), multifocal electroretinography (mfERG) and electro-oculography (EOG). Results:

A 13-year-old boy with psoriasis arthritis had been treated with methotrexate on a weekly basis for 8.5 years. After terminating treatment, his VA, which was reduced to 0.3 in both eyes initially, improved during the following 3 years but did not return to normal. No visual field defects were found with kinetic perimetry. The rod and cone responses in the full-field ERG were markedly reduced in b-wave amplitude initially, but grew slowly to nearly normal values 3 years later. After withdrawal of the drug, the mfERG demonstrated normal responses in the macular region. The Arden index in the EOG was normal. Conclusion:

Chronic treatment with methotrexate may affect VA, and may reversibly reduce rod and cone function. In patients who use systemic medication and whose vision is reduced, objective evaluation of retinal function with electrophysiological methods is recommended.

Keywords: full-field electroretinography; retinal dysfunction; drug side-effects; methotrexate

Document Type: Research article

DOI: 10.1046/j.1600-0420.2003.00181.x

Affiliations: 1: Department of Ophthalmology, University of Lund, Sweden

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Reduced full-field electroretinogram (ERG) in a patient treated with methotrexate