IngentaConnect Vigabatrin-associated loss of vision: rarebit perimetry illuminat...

Author: Frisén, Lars¹

Source: Acta Ophthalmologica Scandinavica, Volume 82, Number 1, February 2004 , pp. 54-58(5)

Abstract:

. Purpose:

The utility of vigabatrin in the treatment of epilepsy is partially offset by its retinal toxicity. The relationship between dosage and damage is obscure. This may be due to perimetric shortcomings. The new technique of rarebit (`microdot') perimetry might be more informative. Methods:

Twelve patients who had been treated with vigabatrin for various durations were examined by manual, kinetic perimetry and by rarebit perimetry. Results:

Rarebit results differed significantly between patients and normal controls and rarebit deficits were directly proportional to cumulated vigabatrin doses (correlation coefficients were − 0.92 in the nasal field and − 0.82 in the temporal field). Manual perimetry results were less clearly related to dosage (r = − 0.54 and r = − 0.73, respectively). Conclusion:

Rarebit perimetry indicates that each treated subject will develop visual loss and that visual loss will be proportional to the accumulated dose. Conventional perimetry is less well suited to detecting and quantifying vigabatrin-associated visual loss.

Keywords: vigabatrin; vision; visual field; perimetry

Document Type: Research article

DOI: 10.1046/j.1600-0420.2003.00184.x

Affiliations: 1: Institute of Clinical Neuroscience, Sahlgren Academy, Gothenburg University, Sweden

You have access to the full text article on a website external to Ingentaconnect.

Please click here to view this article on InterScience.

You may be required to register and activate access on InterScience before you can obtain the full text. If you have any queries please contact onlinehelp@oxon.blackwellpublishing.com

Vigabatrin-associated loss of vision: rarebit perimetry illuminates the dose−damage relationship