Free Content Frequency of HLA class 1 and 2 alleles in Brazilian patients with AIDS and cytomegalovirus retinitis

Authors: de Lourdes Veronese Rodrigues, Maria1; de Castro Figueiredo, José Fernando1; Deghaide, Neifi Hassan Saloum1; Romão, Erasmo1; de Souza, Nivaldo Vieira1; Donadi, Eduardo Antonio1

Source: Acta Ophthalmologica Scandinavica, Volume 81, Number 5, October 2003 , pp. 514-516(3)

Publisher: Blackwell Publishing

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Abstract:

. Purpose: 

To evaluate the human leucocyte antigen (HLA) class 1 (HLA-A and HLA-B) and HLA class 2 (HLA-DRB1 and HLA-DQB1) allele profiles in the susceptibility to cytomegalovirus retinitis (CMV-R) in patients with AIDS. Methods: 

Cytomegalovirus retinitis was clinically diagnosed by indirect binocular ophthalmoscopy. Human leucocyte antigens class 1 were typed using a complement-dependent microlymphocytotoxicity assay, and HLA class 2 alleles were identified using amplified DNA hybridized to sequence-specific oligonucleotide primers. Results: 

The frequencies of HLA class 1 antigens and HLA class 2 alleles observed in patients and controls were similar; however, HLA-A31 antigen was over-represented in patients with AIDS, independent of the presence of CMV-R. Conclusion: 

There was no association between HLA molecules/alleles and CMV-R in Brazilian patients with AIDS. However, the results support the role of the HLA system in the susceptibility to developing AIDS.

Keywords: cytomegalovirus retinitis; histocompatibility leucocyte antigens; acquired immunodeficiency syndrome; risk factor

Document Type: Research article

DOI: 10.1034/j.1600-0420.2003.00098.x

Affiliations: 1: Faculty of Medicine of Ribeirão Preto, University of São Paulo, Brazil

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