IngentaConnect Factor V Leiden and prothrombin gene G20210A mutations in ocular ...

Authors: Batioğlu, Figen¹; Atmaca, Leyla S.¹; Karabulut, Halil Gürhan²; Beyza Sayin, Derya²

Source: Acta Ophthalmologica Scandinavica, Volume 81, Number 3, June 2003 , pp. 283-285(3)

Abstract:

. Purpose:

To investigate genetic prothrombotic factors (factor V Leiden and prothrombin gene G20210A mutations) and their relation with retinal vascular occlusions in ocular Behçet disease. Methods:

Thirty Behçet patients were prospectively recruited into the study. Their mean age was 34.2 ± 8.3 years. All patients underwent complete ophthalmic examination and fluorescein angiography. Of the 30 patients, 15 (16 eyes) had retinal vascular occlusion. Patients were tested for the presence of factor V Leiden and prothrombin gene G20210A mutations by polymerase chain reaction. The results were compared with the frequencies of factor V Leiden in 285 and prothrombin gene G20210A mutation in 182 healthy members of the Turkish population. Results:

The prevalence of factor V Leiden mutation was significantly higher in ocular Behçet patients (12/30, 40%), compared with healthy control subjects (28/285, 9.8%) (p < 0.001). Of the 12 Behçet patients with factor V Leiden mutation, eight had retinal vascular occlusion. The prevalence of factor V Leiden was 53.3% (8/15) of the 15 patients with retinal vascular occlusion and 26.7% (4/15) of the remaining 15 patients without vascular occlusion. Prothrombin gene mutation was detected in none of Behçet patients compared with 2.7% (5/182) of the control group. Conclusion:

These data suggest that factor V Leiden may be an additional risk factor in ocular Behçet disease, whereas factor II mutations do not seem to be relevant.

Keywords: Behçet's disease; procoagulant factors; factor V Leiden mutation; prothrombin G20210A-mutation; vascular occlusion

Document Type: Research article

DOI: 10.1034/j.1600-0420.2003.00068.x

Affiliations: 1: Eye Clinic, Medical School, Ankara University, Turkey 2: Medical Genetics, Medical School, Ankara University, Turkey

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Factor V Leiden and prothrombin gene G20210A mutations in ocular Behçet disease