IngentaConnect Effects of prostaglandins on form deprivation myopia in the chick

Abstract:

.Purpose:

To investigate the possible role of endogenous prostaglandins in the development of form deprivation myopia, as well as the effects of exogenous prostaglandins using atropine as a positive control.

Methods:

Monocular form deprivation was accomplished by mounting a translucent occluder on one eye of 2-3 day old chicks for 1-4 weeks. Ocular occlusion for 1-2 weeks was used for pharmacological blocking experiments. The axial length of the eye was measured by ultrasonography.

Results:

Indomethacin, administered intramuscularly, subconjunctivally or intra-vitreally had no significant effect on myopia development. Exogenous PGE₂, PGF_2α and latanoprost acid administered subconjunctivally, or topically as isopropyl ester eyedrops had no statistically significant effect on the myopia development. However, PGF_2α significantly (p<0.01) attenuated the development of myopia after intravitreal injection. The other two prostaglandins had no statistically significant effect.

Conclusions:

Endogenous prostaglandins are unlikely to play a significant role in the development of form deprivation myopia in the chick. However, PGF_2α suprisingly seems to retard the development of form deprivation myopia, but only when administered intravitreally. Whether the mechanism of the myopia retardation is direct or indirect remains unknown.

Keywords: form deprivation myopia; chick; prostaglandins; PGE2; PGF2; latanoprost; indomethacin

Document Type: Original article

Affiliations: 1: Department of Neuroscience, Unit of Pharmacology, Uppsala University, Uppsala, Sweden