IngentaConnect Early Detection of Decreased Soluble HLA-G Levels in the Maternal...

Authors: Steinborn, Andrea¹; Varkonyi, Tibor¹; Scharf, Alexander²; Bahlmann, Franz³; Klee, Andreas⁴; Sohn, Christof¹

Source: American Journal of Reproductive Immunology, Volume 57, Number 4, April 2007 , pp. 277-286(10)

Publisher: Blackwell Publishing

Abstract:

Problem

Soluble (s) HLA-G1/G5 molecules may potentially affect immune homeostasis during pregnancy. The aim of this study was to determine changes of sHLA-G1/G5 plasma levels throughout normal pregnancy and to assess its predictive value for the occurrence of characteristic gestation-associated diseases during further course of pregnancy. Method of study

sHLA-G1/G5 levels were estimated in plasma samples of 40 non-pregnant women, 291 women throughout normal pregnancy and 236 women affected by different complications. Results

In comparison with non-pregnant women sHLA-G1/G5 levels strongly increased during the first trimenon and then decreased continuously toward term. Non-parametric discriminant analysis showed that women with significantly decreased sHLA-G1/G5 levels in the second trimenon had an increased risk of developing preeclampsia and/or intrauterine growth retardation (IUGR) during further course of pregnancy. However, in the third trimenon, sHLA-G1/G5 levels in affected women did not deviate significantly from those of non-affected women. Surprisingly, significantly increased sHLA-G1/G5 levels were detected in third trimenon women with uncontrollable preterm labor, but not in women with prolonged preterm rupture of fetal membranes. Conclusion

For the identification of women with an increased risk of IUGR and/or preeclampsia, measurement of sHLA-G1/G5 plasma levels may be a powerful new tool in prenatal diagnostics.

Keywords: Intrauterine growth retardation; peripheral tolerance induction; preeclampsia; prolonged preterm rupture of fetal membranes; soluble HLA-G molecules; uncontrollable preterm labor

Document Type: Research article

DOI: 10.1111/j.1600-0897.2007.00475.x

Affiliations: 1: Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany; 2: Department of Obstetrics and Gynecology, Medical Highschool Hannover, Hannover, Germany; 3: Department of Obstetrics and Gynecology, Buergerhospital Frankfurt/Main, Frankfurt/Main, Germany; 4: Department of Obstetrics and Gynecology, Dr. Horst-Schmidt Hospital, Wiesbaden, Germany

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Early Detection of Decreased Soluble HLA-G Levels in the Maternal Circulation Predicts the Occurrence of Preeclampsia and Intrauterine Growth Retardation During Further Course of Pregnancy