IngentaConnect Establishment of the Porcine Epitheliochorial Placenta Is Associa...

Authors: Dimova, Tanya¹; Mihaylova, Anastassia²; Spassova, Petia²; Georgieva, Rayna¹

Source: American Journal of Reproductive Immunology, Volume 57, Number 4, April 2007 , pp. 250-261(12)

Abstract:

Problem

We assessed implantation-associated quantitative changes in peripheral blood and endometrial T lymphocytes throughout epitheliochorial placenta formation. Method of study

T-cell subsets were investigated in 10-, 15-, 20-, 30-, and 40-day pregnant and non-pregnant sows by flow cytometry and immunohistochemistry. Results

Endometrial total T, T cytotoxic (Tc), and T helper (Th) cells were in peak numbers at the attachment phase of implantation and Tc cells persisted in high proportions up to placental establishment. The number of γδ T lymphocytes was relatively small and implantation-independent. In situ, T cells increased in number with the advancement of implantation and formed T-cell clusters with implantation phase-dependent location. Percentages of peripheral blood T cells were not significantly changed throughout the implantation. Conclusion

Superficial and adeciduate implantation of pigs has a profound effect on the number of total T, Tc, and Th cells and pattern of distribution of endometrial T cells in situ.

Keywords: Epitheliochorial placenta; pigs; T cell clusters; T lymphocytes

Document Type: Research article

DOI: 10.1111/j.1600-0897.2007.00472.x

Affiliations: 1: Department of Immunobiology of Reproduction, Institute of Biology and Immunology of Reproduction, Acad.K.Bratanov, Bulgarian Academy of Sciences, Sofia, Bulgaria; 2: Central Laboratory of Clinical Immunology, University Hospital Alexandrovska, Sofia, Bulgaria

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Establishment of the Porcine Epitheliochorial Placenta Is Associated with Endometrial T-Cell Recruitment