IngentaConnect Elevation of Macrophage Colony-Stimulating Factor in Amniotic Flu...

Authors: Hayashi, Masatoshi¹; Hombo, Yoshiyasu²; Shibazaki, Mitsuei³; Nakajima, Atsuko³; Inaba, Noriyuki⁴

Source: American Journal of Reproductive Immunology, Volume 55, Number 3, March 2006 , pp. 226-231(6)

Abstract:

Problem

Macrophage colony-stimulating factor (M-CSF) promotes placental growth and maintenance, and regulates trophoblast invasion into the placental bed. We evaluated whether the amniotic fluid M-CSF levels at the late stage of normal pregnancy is altered compared with those at the middle stage. Method of study

This study enrolled 52 subjects experiencing normotensive pregnancies with single fetuses, of whom 26 were women at the late stage (term gravidas) and 26 were women at the middle stage (controls). The average gestational age at entry was 38 weeks of gestation and 17 weeks, respectively. Amniotic fluid was collected from these subjects. Amniotic fluid M-CSF levels were determined by the enzyme-linked immunosorbent assay method then compared between term gravidas and controls. Results

Amniotic fluid M-CSF concentrations were 4815 pg/mL (median) in term gravidas and 3795 pg/mL in controls; the concentrations were significantly higher in term gravidas than in controls. Conclusions

We demonstrated a significant increase in amniotic fluid M-CSF levels in term gravidas. These results suggest that elevated levels of M-CSF in amniotic fluid have an important immunological function in the maintenance of pregnancy and fetal growth.

Keywords: Amniotic fluid; late stage of pregnancy; macrophage colony-stimulating factor; middle stage of pregnancy; uncomplicated normotensive pregnancies

Document Type: Research article

DOI: 10.1111/j.1600-0897.2005.00352.x

Affiliations: 1: Department of Obstetrics and Gynecology, International University of Health and Welfare Atami Hospital, Higashikaigan-cho, Atami-shi, Shizuoka, Japan; 2: Department of Obstetrics and Gynecology, Kanazawa Holy Spirit Hospital, Nagamachi, Kanazawa-shi, Ishikawa, Japan; 3: Department of Clinical Laboratory, Koshigaya Hospital, Dokkyo University School of Medicine, Minami-Koshigaya, Koshigaya-shi, Saitama, Japan; 4: Department of Obstetrics and Gynecology, Dokkyo University School of Medicine, Kitakobayashi, Mibu, Shimotsuga, Tochigi, Japan

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Elevation of Macrophage Colony-Stimulating Factor in Amniotic Fluid at Late Stage of Normal Pregnancy