IngentaConnect Cognitive behaviour therapy and medication in the treatment of ob...

Authors: O'Connor, K. P.¹; Aardema, F.¹; Robillard, S.¹; Guay, S.¹; Pélissier, M.-C.¹; Todorov, C.²; Borgeat, F.²; Leblanc, V.¹; Grenier, S.¹; Doucet, P.¹

Source: Acta Psychiatrica Scandinavica, Volume 113, Number 5, May 2006 , pp. 408-419(12)

Publisher: Blackwell Publishing

Abstract:

O'Connor KP, Aardema F, Robillard S, Guay S, Pélissier M-C, Todorov C, Borgeat F, Leblanc V, Grenier S, Doucet P. Cognitive behaviour therapy and medication in the treatment of obsessive–compulsive disorder. Objective:

To compare cognitive behaviour therapy (CBT) with CBT plus medication; medication alone; and placebo in the treatment of adult obsessive–compulsive disorder (OCD). Method:

Forty-eight participants (43 completers) were recruited into two protocols. In the first protocol, 21 people with OCD were randomly allocated to either a standard medication (fluvoxamine) or standard placebo condition for a 5-month period. Both these groups subsequently received CBT for a further 5 months. In the second protocol, 22 people with OCD received CBT, one group was already stabilized on an antidepressant of choice; the second group was drug naïve. Results:

All active treatments, but not the placebo, showed clinical improvement. There was no difference in treatment response to CBT regardless of whether participants had previously received medication or placebo. Conclusion:

CBT has a more specific antiobsessional effect than medication but CBT plus medication shows greatest overall clinical improvement in mood.

Keywords: cognitive therapy; cognitive behaviour; drug therapy; obsessive behaviour; anxiety; depression

Document Type: Research article

DOI: 10.1111/j.1600-0447.2006.00767.x

Affiliations: 1: Fernand-Seguin Research Centre, Louis-H. Lafontaine Hospital, Montreal, QC, Canada 2: Louis-H. Lafontaine Hospital, Montreal, QC, Canada

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