@article {Monastero:January 2006:0001-690X:59,
	author = "Monastero, R.",
	author = "Mariani, E.",
	author = "Camarda, C.",
	author = "Ingegni, T.",
	author = "Averna, M. R.",
	author = "Senin, U.",
	author = "Camarda, R.",
	author = "Mecocci, P.",
	title = "Association between apolipoprotein E 4 allele and apathy in probable Alzheimer's disease",
	journal = "Acta Psychiatrica Scandinavica",
	volume = "113",
	year = "January 2006",
	abstract = "Monastero R, Mariani E, Camarda C, Ingegni T, Averna MR, Senin U, Camarda R, Mecocci P. Association between apolipoprotein E &#603;4 allele and apathy in probable Alzheimer's disease. &#60;br /&#62;Acta Psychiatr Scand 2005: 1&#8211;5. &#169; 2005 Blackwell Munksgaard. Objective:&#8194; <P></P>There have been inconclusive results to date on the association between the Apolipoprotein E (ApoE) genotype and neuropsychiatric symptoms (NPS) in Alzheimer's disease (AD). We investigated whether ApoE <I>&#603;</I>4 allele is associated with NPS in probable AD. Method:&#8194; <P></P>Data for 197 subjects with probable AD were analysed. The Neuropsychiatric Inventory was used to evaluate the frequency and severity of NPS. Multiple logistic regression models were used to test the association between ApoE genotype and NPS in AD. Results:&#8194; <P></P>The ApoE <I>&#603;</I>3/3 genotype was present in 52.3%, <I>&#603;</I>3/4 in 44.1%, and <I>&#603;</I>4/4 in 3.6% of patients. ApoE <I>&#603;</I>4 carriers showed a higher frequency of apathy than non-carriers. After multiple adjustments, the ApoE <I>&#603;</I>4 allele was significantly associated with apathy. Conclusion:&#8194; <P></P>Our results suggest a relationship between the ApoE <I>&#603;</I>4 allele and apathy in patients with AD.",
	pages = "59-63(5)",
	url = "http://www.ingentaconnect.com/content/mksg/acp/2006/00000113/00000001/art00010"
	doi = "doi:10.1111/j.1600-0447.2005.00597.x"
}