@article {Fan:January 2006:0001-690X:48,
	author = "Fan, P.-L.",
	author = "Chen, C.-D.",
	author = "Kao, W.-T.",
	author = "Shu, B.-C.",
	author = "Lung, F.-W.",
	title = "Protective effect of the apo 2 allele in major depressive disorder in Taiwanese",
	journal = "Acta Psychiatrica Scandinavica",
	volume = "113",
	year = "January 2006",
	abstract = "Fan P-L, Chen C-D, Kao W-T, Shu B-C, Lung F-W. Protective effect of the apo &#603;2 allele in major depressive disorder in Taiwanese. &#60;br /&#62;Acta Psychiatr Scand 2005: 1&#8211;6. &#169; 2005 Blackwell Munksgaard. Objective:&#8194; <P></P>Major depression is an important comorbidity in Alzheimer's disease, which is definitely associated with the apolipoprotein E (apo E) polymorphism. The aim of this study was to explore the role of the different apo E polymorphisms in major depressive disorder (MDD) in a Taiwanese population. Method:&#8194; <P></P>We examined apo E genotypes in 273 Taiwanese patients with MDD and 429 healthy community controls, and compared their polymorphism distribution. Results:&#8194; <P></P>The allelic frequency of apo <I>&#603;</I>2 was significantly lower in patients with MDD than in the controls, whereas no significant difference in apo <I>&#603;</I>4 allelic frequency between these two groups was found. Conclusion:&#8194; <P></P>The apo <I>&#603;</I>4 allele was not associated with MDD in this study. However, the finding of a lower frequency of the apo <I>&#603;</I>2 allele in MDD could lead to the conclusion that the apo <I>&#603;</I>2 allele likely provides a protective effect against MDD in the Taiwanese population.",
	pages = "48-53(6)",
	url = "http://www.ingentaconnect.com/content/mksg/acp/2006/00000113/00000001/art00008"
	doi = "doi:10.1111/j.1600-0447.2005.00686.x"
}