IngentaConnect Cognitive performance following fluoxetine treatment in depressed...

Authors: Strik, Jacqueline J. M. H.¹; Honig, Adriaan¹; Klinkenberg, Edwin¹; Dijkstra, Jeanette¹; Jolles, Jelle¹

Source: Acta Neuropsychiatrica, Volume 18, Number 1, February 2006 , pp. 1-6(6)

Abstract:

Strik JJMH, Honig A, Klinkenberg E, Dijkstra J, Jolles J. Cognitive performance following fluoxetine treatment in depressed patients post myocardial infarction. Background:

As depression is a considerable risk factor for an unfavourable course of myocardial infarction (MI), antidepressant treatment of post-MI depression and, inherent to MI status, polypharmacy has become an important issue. Objective:

The present study is the first to evaluate cognitive side effects of fluoxetine, as part of a placebo-controlled double-blind trial, in patients with post-first MI depression. Methods:

Cognitive performance of 54 depressed patients post first-MI, treated with fluoxetine or placebo was compared. Cognitive performance was tested before and after 9 weeks of treatment using the Visual Verbal Learning Test, Concept Shifting Task, Stroop Colour-Word Test and Letter-Digit-Substitution Test. Results:

The median number of cardiovascular drugs taken by MI patients was 4.9. There were no differences between the fluoxetine and the placebo group on cognitive performance. Conclusion:

In sum, there were no negative side effects of fluoxetine compared with placebo on cognition in depressed MI patients, simultaneously treated with cardiac drugs.

Keywords: cognition; depression; fluoxetine; myocardial infarction; side effects

Document Type: Research article

DOI: 10.1111/j.0924-2708.2006.00110.x

Affiliations: 1: Department of Psychiatry, University Hospital Maastricht/University of Maastricht, The Netherlands

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