@article {Mizukoshi:September 2005:0161-6412:644,
	author = "Mizukoshi, Genki",
	author = "Katsura, Ken-ichiro",
	author = "Katayama, Yasuo",
	title = "Urinary 8-hydroxy-2-deoxyguanosine and serum S100beta in acute cardioembolic stroke patients",
	journal = "Neurological Research",
	volume = "27",
	year = "September 2005",
	abstract = "<B>Objective:</B> Our aim was to explore whether free radical damage against DNA exists or not, in human stroke patients.<P></P><B>Method:</B> Urinary 8-hyroxy-2<IMG SRC="/iso-ents/isotech/prime.gif" ALT="prime">-deoxyguanosine (8-OHdG) and serum S100<I><IMG SRC="/iso-ents/isogrk32/beta-s.gif" ALT="beta"></I> were measured in acute cardioembolic stroke patients with relatively severe symptoms. During days 3&#150;5 after the onset of stroke, urine was collected for 24 hours for 8-OHdG measurement and serum was sampled for S100<I><IMG SRC="/iso-ents/isogrk32/beta-s.gif" ALT="beta"></I> analysis every day.<P></P><B>Results:</B> The total urinary 8-OHdG content was significantly higher in stroke patients than in non-stroke inpatients (<I>p</I>&#060;0.01). The average value was more than twice the value of that of non-stroke inpatients. The total urinary 8-OHdG contents showed significant correlation (<I>r</I>=0.87, <I>p</I>&#060;0.01) with serum S100<I><IMG SRC="/iso-ents/isogrk32/beta-s.gif" ALT="beta"></I> values, which are reportedly related to brain damage.<P></P><B>Discussion:</B> These findings suggest that urinary 8-OHdG in acute stroke patients may originate from brain tissue, and DNA damage also exists in the brain of stroke patients.",
	pages = "644-646(3)",
	url = "http://www.ingentaconnect.com/content/maney/nres/2005/00000027/00000006/art00013"
	doi = "doi:10.1179/016164105X25153"
}