@article {Taniguchi:September 2005:0161-6412:613,
	author = "Taniguchi, Tamiki",
	author = "Morikawa, Eiharu",
	author = "Mori, Takashi",
	author = "Matsui, Toru",
	title = "Neuroprotective efficacy of selective brain hypothermia induced by a novel external cooling device on permanent cerebral ischemia in rats",
	journal = "Neurological Research",
	volume = "27",
	year = "September 2005",
	abstract = "<B>Objectives:</B> This study was aimed at examining whether hypothermia is neuroprotective against permanent cerebral ischemia in rats.<P></P><B>Methods:</B> A total of 32 male Sprague&#150;Dawley rats were subjected to a middle cerebral artery occlusion. In the hypothermic group, rats (n= 10) underwent selective brain hypothermia for 5 hours with the use of a novel surface coil with coolant circulating inside. In the control (n= 13) and sham groups (n=9), the rats were maintained at normothermia. After a period of 168 hours ischemia, animals were killed to measure the infarction volume of the brain stained with hematoxylin-eosin.<P></P><B>Results:</B> There were no significant differences in physiological parameters except for the temperature. The present style of hypothermia significantly reduced infarction volume in the cortex and caudoputamen.<P></P><B>Discussion:</B> The present results endorse the neuroprotective effect of our method of hypothermia in permanent focal cerebral ischemia at an endpoint of 1 week under the following two conditions: (1) reduction of muscle and caudoputamen temperature to 29 and 31&#176;C, respectively; (2) maintenance of the mean arterial blood pressure above 90 mmHg during hypothermia.",
	pages = "613-619(7)",
	url = "http://www.ingentaconnect.com/content/maney/nres/2005/00000027/00000006/art00007"
	doi = "doi:10.1179/016164105X22110"
}