@article {Chen:September 2006:0272-4936:181,
	author = "Chen, Shih-Hsiang",
	author = "Yen, Meng Hsiu",
	author = "Chiu, Cheng-Hsun",
	author = "Yan, Dah-Chin",
	author = "Hsu, Chih-Yi",
	author = "Lin, Tzou-Yien",
	title = "Clinical observation of meningitis caused by penicillin-susceptible and -non-susceptible Streptococcus pneumoniae in Taiwanese children",
	journal = "Annals of Tropical Paediatrics: International Child Health",
	volume = "26",
	year = "September 2006",
	abstract = "<I>Aim</I>: To compare differences between clinical features and outcome in bacterial meningitis caused by penicillin-susceptible <I>Streptococcus pneumoniae</I> (PSSP) with that caused by penicillin-non-susceptible <I>Streptococcus pneumoniae</I> (PNSP).<P></P><I>Methods</I>: All patients &#60;18 yrs hospitalised with pneumococcal meningitis between January 1984 and December 2002 at Chang Gung Children's Hospital, Taipei were reviewed retrospectively.<P></P><I>Results</I>: There were 28 PNSP (63.6%) and 16 PSSP cases of meningitis eligible for the study. The incidence of PNSP meningitis increased significantly over the 8-yr period (<I>p</I>=0.007). Age &#60;4 yrs (78.6% <I>vs</I> 50%), a lower initial white blood count (mean 11.7 <I>vs</I> 19.9 &#215;10<SUP>9</SUP>/L), admission to the intensive care unit (70.4% <I>vs</I> 50%) and mortality (28.6% <I>vs</I> 6.3%) were more common in the PNSP group. However, the only significant finding was a lower proportion of polymorphic neutrophils in the CSF of the PNSP meningitis group (<I>p</I>=0.04).<P></P><I>Conclusions</I>: There was an increase in PNSP isolates from patients with meningitis over the 8-yr study period. No major differences were observed in clinical or laboratory features or outcome between the PSSP and PNSP groups.",
	pages = "181-185(5)",
	url = "http://www.ingentaconnect.com/content/maney/atp/2006/00000026/00000003/art00003"
	doi = "doi:10.1179/146532806X120264"
}