@article {Alcais:December 2001:1385-0229:237,
	author = "Alcais A.",
	author = "Remus N.",
	author = "Abel L.",
	author = "Casanova J-L.",
	title = "Genetic Susceptibility to Tuberculosis: From Monogenic to Polygenic Inheritance",
	journal = "Sepsis",
	volume = "4",
	year = "December 2001",
	abstract = "<P>Summary. Tuberculosis is re-emerging as a leading public health problem worldwide, largely due to the lack of a fully protective vaccine, the acquired immunodeficiency associated with HIV-co-infection and the increasing number of drug-resistant mycobacteria. There is substantial epidemiological evidence that the host genetic make-up affects the development of clinical tuberculosis in humans. Here we review population-based and patient-based molecular studies that have implicated various genes in polygenic and monogenic susceptibility to mycobacterial disease. We further discuss the possibility of a continuous spectrum between these two poles of tuberculosis genetics.</P>",
	pages = "237-246(10)",
	url = "http://www.ingentaconnect.com/content/klu/seps/2001/00000004/00000003/00386333"
}