@article {Kulagova:September 2006:0090-2977:338,
author = "Kulagova, T.",
author = "Semenkova, G.",
author = "Kvacheva, Z.",
author = "Ripich, T.",
author = "Koren, S.",
title = "Effect of peroxynitrite on production of superoxide anion radicals and calcium homeostasis in cells of astroglial origin",
journal = "Neurophysiology",
volume = "38",
year = "September 2006",
abstract = "We studied the effect of a donor of peroxynitrite, SIN-1, on the morphological characteristics of interweaved rat C6 glioma cells, on menadione-induced production of superoxide anion radicals, and on the concentration of Ca2+ in these cells. In concentrations of 1.25·10−4 to 2.5·10−7 M, SIN-1 demonstrated cytotoxic and antimitogenic effects. This donor of peroxynitrite caused abnormal modifications of the size of C6 cells and the structure of cellular organelles, intensified in a dose-dependent manner the release of Ca2+ from cellular stores into the cytoplasm, and suppressed menadione-induced production of superoxide anion radicals. Therefore, it should be believed that peroxynitrite exerts a modifying effect on the processes of mitotic division and induces apoptosis; it is also involved in the processes of intracellular signalling providing an increase in the concentration of cytosolic Ca2+ and a decrease in the redox activity of cells.",
pages = "338-343(6)",
url = "http://www.ingentaconnect.com/content/klu/neph/2006/00000038/F0020005/00000068"
doi = "doi:10.1007/s11062-006-0068-0"
}