@article {Kato:September 1998:0393-2990:621, author = "Kato I.", author = "Vogelman J.H.", author = "Dilman V.", author = "Karkoszka J.", author = "Frenkel K.", author = "Durr N.P.", author = "Orentreich N.", author = "Toniolo P.", title = "Effect of supplementation with chromium picolinate on antibody titers to 5-hydroxymethyl uracil", journal = "European Journal of Epidemiology", volume = "14", year = "September 1998", abstract = "

Recent in vitro studies have shown that chromium (III) compounds such as chromium picolinate, a popular dietary supplement among people trying to lose weight, produce chromosome damage. We monitored levels of DNA damage in a chromium picolinate supplement trial by measuring antibodies titers to an oxidized DNA base, 5-hydroxymethyl-2'-deoxyuridine (HMdU), by enzyme-linked immunosorbent assays. Ten obese volunteer women completed a 8-week course of 400 mgrg chromium picolinate per day. In either absolute titers or percent of the baseline value, there were no changes in antibody titers at 4 or 8 weeks. The titers were very stable within individuals and those of one individual rarely crossed over others, which was reflected in an intraclass correlation coefficient of 0.99 (95% confidence interval: 0.96–1.00). There were no effects on glucose and lipid metabolism in this period. The results of this trial suggest that chromium (III) picolinate in a dose typically used for nutrient supplementation dose not increase oxidative DNA damage, as measured by anti-HMdU antibody levels.

", pages = "621-626(6)", url = "http://www.ingentaconnect.com/content/klu/ejep/1998/00000014/00000006/00169002" }