@article {Pratha:September 2006:0163-2116:1595,
	author = "Pratha, Vijaya",
	author = "Hogan, Daniel",
	author = "Lynn, Richard",
	author = "Field, Brian",
	author = "Metz, David",
	title = "Intravenous Pantoprazole as Initial Treatment in Patients With Gastroesophageal Reflux Disease and a History of Erosive Esophagitis: A Randomized Clinical Trial",
	journal = "Digestive Diseases and Sciences",
	volume = "51",
	year = "September 2006",
	abstract = "We sought to evaluate safety and efficacy of IV pantoprazole when used as initial therapy in patients with gastroesophageal reflux disease (GERD) and a history of erosive esophagitis (EE) in a double-blind, placebo-controlled, randomized, parallel-group study. Patients were randomized to 7 days of once-daily IV or oral pantoprazole (40 mg) or placebo. Efficacy variables included maximal acid output, basal acid output, and changes from baseline in frequency/severity of GERD symptoms, and frequency of antacid usage. Seventy-eight patients were randomized (<I>n=</I>26/27/25 [IV/oral/placebo]). Mean maximal acid output was 8.4, 6.3, and 20.9 mEq/h for IV or oral pantoprazole, and placebo, respectively. For pantoprazole versus placebo, maximal and basal acid output were significantly lower (<I>P</I>&#60;.001) and there was a numerical trend toward improved GERD and antacid usage. Both treatments were well tolerated. In conclusion, IV/oral pantoprazole were similarly effective in suppressing basal and pentagastrin-stimulated gastric acid secretion in GERD patients with a history of EE.",
	pages = "1595-1601(7)",
	url = "http://www.ingentaconnect.com/content/klu/ddas/2006/00000051/00000009/00009108"
	doi = "doi:10.1007/s10620-006-9108-2"
}