@article {Naito:October 2005:0163-2116:S104,
	author = "Naito, Yuji",
	author = "Kajikawa, Hirokazu",
	author = "Mizushima, Katsura",
	author = "Shimozawa, Makoto",
	author = "Kuroda, Masaaki",
	author = "Katada, Kazuhiro",
	author = "Takagi, Tomohisa",
	author = "Handa, Osamu",
	author = "Kokura, Satoshi",
	author = "Ichikawa, Hiroshi",
	author = "Yoshida, Norimasa",
	author = "Matsui, Hirofumi",
	author = "Yoshikawa, Toshikazu",
	title = "Rebamipide, a Gastroprotective Drug, Inhibits Indomethacin-Induced Apoptosis in Cultured Rat Gastric Mucosal Cells: Association with the Inhibition of Growth Arrest and DNA Damage-Induced 45alpha Expression",
	journal = "Digestive Diseases and Sciences",
	volume = "50",
	year = "October 2005",
	abstract = "Rebamipide, a gastromucosal protective drug, suppresses indomethacin-induced gastropathy in humans and rodents. Effects of rebamipide on gene expression in indomethacin-treated gastric mucosal cells (RGM1) were investigated using high-density oligonucleotide arrays. Indomethacin induced apoptosis in RGM1 cells in a dose-dependent manner. Rebamipide pretreatment significantly reduced indomethacin-induced apoptosis. We used gene expression profiling on high-density oligonucleotide probe arrays to characterize the transcriptional response of RGM1 cells to indomethacin treatment for 6 hr. Of the 8,799 probes examined, 717 (8.1&#037;) were induced (400 probes) or repressed (317 probes) at least 1.5-fold. Among the 158 genes that were induced by indomethacin at least 2.0-fold, four genes that were down-regulated by rebamipide at least 2.0-fold are listed: growth arrest and DNA-damage-inducible 45<IMG SRC="/iso-ents/isogrk32/alpha-s.gif" ALT="alpha"> (GADD45<IMG SRC="/iso-ents/isogrk32/alpha-s.gif" ALT="alpha">), golgi SNAP receptor complex member 1, iodothyronine deiodinases, and transcription factor 8. Real time-PCR confirmed GADD45<IMG SRC="/iso-ents/isogrk32/alpha-s.gif" ALT="alpha"> expression and its inhibition by rebamipide. Inhibition of apoptosis-related genes is possibly important for the cytoprotective effect of rebamipide against indomethacin-induced gastric mucosal cell injury.",
	pages = "S104-S112(1)",
	url = "http://www.ingentaconnect.com/content/klu/ddas/2005/00000050/A00100s1/00002814"
	doi = "doi:10.1007/s10620-005-2814-3"
}