@article {Udupa:February 2004:0040-5752:550,
	author = "Udupa, S.",
	author = "Malhotra, R.",
	author = "Baum, M.",
	title = "Tightly linked di- and tri-nucleotide microsatellites do not evolve in complete independence: evidence from linked (TA) n and (TAA) n microsatellites of chickpea (Cicer arietinum L.)",
	journal = "Theoretical and Applied Genetics",
	volume = "108",
	year = "February 2004",
	abstract = "In order to understand the dynamics of microsatellite evolution, we have studied allelic variation at a closely linked (TA)<SUB> <I>n</I> </SUB> and (TAA)<SUB> <I>n</I> </SUB> microsatellite loci in 114 land races of chickpea (<I>Cicer arietinum</I> L.), sampled worldwide. These two loci are separated by 27&#160;bp. The two loci showed a very high degree of polymorphism and hence the combined length with the genetic diversity of 0.93, 0.90 and 0.98 for (TAA)<SUB> <I>n</I> </SUB>, (TA)<SUB> <I>n</I> </SUB> and the combined length, respectively. Using the variation data at the linked loci, a standardized index of linkage disequilibrium was also computed (<I>I</I> <SUP> <I>S</I> </SUP> <SUB> <I>A</I> </SUB>=0.092), which tests the null hypothesis of no linkage and was significant, indicating the presence of linkage disequilibrium. Furthermore, the dynamics of allelic variation showed that there is a threshold combined length, below which both (TAA)<SUB> <I>n</I> </SUB> and (TA)<SUB> <I>n</I> </SUB> loci evolve independently, and above which, if one locus increase in size, the other closely linked locus has a tendency to decrease its size and vice versa, without change in the overall ratio of (TAA)<SUB> <I>n</I> </SUB> and (TA)<SUB> <I>n</I> </SUB> allele sizes at the region. This result indicates that there are processes in the cell, which `read' the combined size of the two loci both for proportion and length and determine the direction of tightly linked di- and tri-nucleotide repeat evolution.",
	pages = "550-557(8)",
	url = "http://www.ingentaconnect.com/content/klu/122/2004/00000108/00000003/art00020"
	doi = "doi:10.1007/s00122-003-1458-y"
}