@article {Grimaldo:June 2001:1027-3719:546,
	author = "Grimaldo E. R.",
	author = "Tupasi T. E.",
	author = "Rivera A. B.",
	author = "Quelapio Ma. I. D.",
	author = "Cardano R. C.",
	author = "Derilo J. O.",
	author = "Belen V. A.",
	title = "Increased resistance to ciprofloxacin and ofloxacin in multidrug-resistant Mycobacterium tuberculosis isolates from patients seen at a tertiary hospital in the Philippines",
	journal = "The International Journal of Tuberculosis and Lung Disease",
	volume = "5",
	year = "June 2001",
	abstract = "<P>SETTING: A hospital-based study at the Makati Medical Center, Makati City, Philippines, a hyperendemic area for tuberculosis (TB).</P><P>OBJECTIVE: To determine the susceptibility of <I>Mycobacterium tuberculosis</I> to ciprofloxacin and ofloxacin.</P><P>DESIGN: Retrospective analysis of drug susceptibility tests (DST) of <I>M. tuberculosis</I> isolated from 1995&#150;2000.</P><P>RESULTS: Resistance to ciprofloxacin was 26.8%, ofloxacin 35.3%, and multidrug resistance (MDR) was 17.2%. Of the MDR strains, 51.4% were resistant to ciprofloxacin and ofloxacin. Acquired resistance was significantly higher for all first-line drugs and for ciprofloxacin, but not for ofloxacin. A significant increase in resistance to ciprofloxacin and ofloxacin was noted compared to 1989&#150;1994, while resistance to the first-line drugs was not significantly different.</P><P>CONCLUSION: Ciprofloxacin and ofloxacin are now a significantly less effective alternative therapy in tuberculosis, particularly MDR-TB, due to a selection pressure from their widespread use in the treatment of TB and possibly other infections in the community, which is hyperendemic for tuberculosis.</P>",
	pages = "546-550(5)",
	url = "http://www.ingentaconnect.com/content/iuatld/ijtld/2001/00000005/00000006/art00010"
}