Effects of excessive copper intake on hematological and hemorheological parameters

Authors: Özçelik, D.¹; Toplan, S.¹; Özdemir, S.¹; Akyolcu, M.¹

Source: Biological Trace Element Research, Volume 89, Number 1, October 2002 , pp. 35-42(8)

Publisher: Humana Press

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Abstract:

Copper plays an important role in the structure and function of metalloproteins and in the absorption of iron. The present study deals with the effects of excessive copper intake on hematological and hemorheological parameters.

Drinking water containing 250 µg/mL copper for a period of 9 wk, Wistar albino rats showed increased erythrocyte count, blood viscosity, and hematocrit values (p<0.05) and lower hemoglobin (p<0.05) than controls fed a normal diet. The two groups also had differences in the erythrocyte deformability index.

The results suggest that excessive copper intake results in hematological and hemorheological changes affecting both the protein content of the erythrocyte membrane and heme synthesis.

Keywords: Copper; trace elements; erythrocyte deformability; blood viscosity; hematological parameters

Document Type: Research article

DOI: 10.1385/BTER:89:1:35

Affiliations: 1: Department of Biophysics, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey,

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