@article {Suka:December 2004:1473-7167:617,
	author = "Suka, Machi",
	author = "Yoshida, Katsumi",
	title = "Cost effectiveness of leflunomide in the treatment of rheumatoid arthritis in Japan",
	journal = "Expert Review of Pharmacoeconomics and Outcomes Research",
	volume = "4",
	year = "December 2004",
	abstract = "Macro-level economic evaluations of drugs are expected to provide useful information for making the decision of whether to approve a newly developed drug as a first-line treatment. Leflunomide has been hoped to be an alternative to existing disease-modifying antirheumatic drugs, but has also raised questions about its cost effectiveness due to the high drug cost and high percentage of withdrawals due to adverse events. A method of cost-effective analysis using disability-adjusted life years, which makes it possible to assess the cost effectiveness of a drug at the macro level, is proposed. Using the proposed method, the cost effectiveness of leflunomide in the treatment of rheumatoid arthritis in Japan is determined.",
	pages = "617-622(6)",
	url = "http://www.ingentaconnect.com/content/ftd/erp/2004/00000004/00000006/art00007"
	doi = "doi:10.1586/14737167.4.6.617"
}