@article {Samarghandian:2016:0008-4212:388,
author = "Samarghandian, Saeed and Azimi-Nezhad, Mohsen and Samini, Fariborz and Farkhondeh, Tahereh",
title = "Chrysin treatment improves diabetes and its complications in liver, brain, and pancreas in streptozotocin-induced diabetic rats",
journal = "Canadian Journal of Physiology and Pharmacology",
volume = "94",
number = "4",
year = "2016",
publication date ="2016-01-01T00:00:00",
abstract = "Chrysin (CH) is a natural flavonoid with pharmacological influences. The purpose of the current study was the assessment of possible protective effects of CH against oxidative damage in the serum, liver, brain, and pancreas of streptozotocin (STZ)- induced diabetic rats. In the present
study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, 3 CH (20, 40, 80 mg/kg/day)-treated diabetic groups. To find out the modulations of cellular antioxidant defense systems, malondialdehyde (MDA) level and antioxidant enzymes including glutathione-S-transferase
(GST), superoxide dismutase (SOD), and catalase (CAT) activities were determined in the serum, liver, brain, and pancreas. STZ caused an elevation of glucose, MDA, TG, TC, LDL-C and with reduction of HDL-C, total protein, SOD, CAT, and GST in the serum, liver, brain, and pancreas (p
p < 0.05). The
current study offers that CH may be recovered diabetes and its complications by modification of oxidative stress.",
pages = "388-393",
itemtype = "ARTICLE",
parent_itemid = "infobike://cndscipub/cjpp",
issn = "0008-4212",
publishercode ="cndscipub",
url = "http://www.ingentaconnect.com/content/cndscipub/cjpp/2016/00000094/00000004/art00006",
doi = "doi:10.1139/cjpp-2014-0412",
keyword = "foie, brain, pancréas, indices oxydatifs, rat, liver, diabète, sérum, streptozotocine, chrysine, diabetes, streptozotocin, cerveau, pancreas, oxidative indices, chrysin, serum"
}