IngentaConnect Cosmetic Outcome and Incidence of Infection with the MammoSite Br...

Abstract:

We present our results regarding the cosmetic outcome achieved and the rate of infection using the MammoSite breast brachytherapy applicator to treat patients with partial breast irradiation. In addition, factors associated with cosmetic outcome and infection are analyzed. The study population consisted of 30 patients with early stage breast cancer treated using the MammoSite device from October 28, 2002, to February 13, 2004. Cosmetic outcome was analyzed for its association with the following parameters: volume of the balloon, balloon-to-skin distance, maximal skin point dose per fraction, V₁₀₀ (percent of volume that received 100% of the prescription dose), V₁₅₀ (percent of volume that received 150% of the prescription dose), and V₂₀₀ (percent of volume that received 200% of the prescription dose). The occurrence of infection at the time of treatment and during follow-up was also recorded. At a median follow-up of 13 months (range 1–16 months), 53.3% of the patients (16/30) were reported to have an excellent cosmetic outcome and 40.0% (12/30) had a good cosmetic outcome. Excellent cosmetic outcome was associated with a greater mean balloon-to-skin distance compared to those who achieved a good cosmetic outcome (1.5 cm versus 1.2 cm) (p = 0.164). The mean V₁₀₀, V₁₅₀, and V₂₀₀ of those in the excellent cosmetic outcome group were 92.1%, 34.5%, and 7.6% versus 93.0%, 34.7%, and 7.6% in the good cosmetic outcome group (p = 0.642, 0.926, and 0.853), The mean balloon volumes were 47.7 cm³ and 56.9 cm³, respectively (p = 0.063) in the excellent and good outcome groups. The mean maximal skin doses per fraction in the excellent and good outcome groups were 354.8 cGy and 422.3 cGy (p = 0.286), respectively. Infection occurred in 13.3% of the patients (4/30). An excellent or good cosmetic outcome was achieved in 93.3% of patients and infection occurred in 13.3% of patients treated with the MammoSite breast brachytherapy applicator. Excellent cosmetic outcome was associated with a greater balloon-to-skin distance, lower maximal skin dose per fraction, and smaller mean balloon volume; however, the results did not reach statistical significance.

Keywords: brachytherapy; breast cancer; MammoSite; radiation

Document Type: Research article

DOI: 10.1111/j.1075-122X.2005.00014.x

Affiliations: 1: Departments of Radiation Oncology and 2: General Surgery and 3: Biostatistics Unit, Department of Medicine, Rush University Medical Center, Chicago, Illinois

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Cosmetic Outcome and Incidence of Infection with the MammoSite Breast Brachytherapy Applicator