Microtome Shaving Radiography: Demonstration of Loss of Mammographic Microcalcifications During Histologic Sectioning

Authors: Winston J.S.; Geradts J.¹; Liu D.F.¹; Stomper P.C.²

Source: The Breast Journal, Volume 10, Number 3, May 2004 , pp. 200-203(4)

Publisher: Blackwell Publishing

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Abstract:

Mammographic-pathologic correlation of suspicious microcalcifications is essential for optimal diagnosis and local staging of early breast carcinoma. Loss of microcalcifications during histologic sectioning has been suggested as one reason for the occasional lack of microscopic visualization of microcalcifications in routinely processed breast biopsy specimens obtained for suspicious mammographic microcalcifications. Two case reports utilizing radiography of histologic shavings of stereotactic core biopsies and surgical excisional biopsies of mammographic microcalcifications provide concrete evidence of the loss of large calcific particles during the microtome process.

Keywords: mammography; microcalcification; tissue sectioning

Document Type: Research article

DOI: 10.1111/j.1075-122X.2004.21300.x

Affiliations: 1: Pathology and Laboratory Medicine, and 2: Diagnostic Imaging, Roswell Park Cancer Institute, Buffalo, New York

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